Journal
MOLECULAR PHARMACEUTICS
Volume 11, Issue 5, Pages 1479-1488Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mp400657g
Keywords
hyaluronic acid; bovine serum albumin; nanodispersion; transdermal transport; skin penetration
Funding
- Fundacao para a Ciencia e a Tecnologia [SFRH/BPD/46515/2008, SFRH/BPD/47555/2008]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/47555/2008] Funding Source: FCT
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A novel transdermal hyaluronic acid (HA) conjugated with bovine serum albumin (BSA) was developed in the form of solid-in-oil (S/O) nanodispersion (129.7 nm mean diameter). Ex vivo skin penetration analysis by fluorescence and confocal observation of histological skin sections revealed the ability of BSA/HA nanodispersions to cross the stratum corneum and penetrate into the dermis. Furthermore, no significant toxicity was found in fibroblast and keratinocyte cells in vitro. These results proved the potential of the developed nanodispersion for transdermal delivery of hyaluronic acid constituting a high value to biopharmaceutical and cosmetics industries.
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