Journal
MOLECULAR PHARMACEUTICS
Volume 10, Issue 4, Pages 1368-1377Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mp3006402
Keywords
cubosomes; drug delivery; self-assembly; computational modeling; nanophase prediction; experimental validation; SAXS
Funding
- CSIRO Advanced Materials Transformational Platform
- Chemical Structure Association Trust Jacques-Emile Dubois Award
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Amphiphilic lyotropic liquid crystalline self-assembled nanomaterials have important applications in the delivery of therapeutic and imaging agents. However, little is known about the effect of the incorporated drug on the structure of nanoparticles. Predicting these properties is widely considered intractable. We present computational models for three drug delivery carriers, loaded with 10 drugs at six concentrations and two temperatures. These models predicted phase behavior for 11 new drugs. Subsequent synchrotron small-angle X-ray scattering experiments validated the predictions.
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