Journal
MOLECULAR PHARMACEUTICS
Volume 10, Issue 1, Pages 33-42Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mp300240m
Keywords
viral nanoparticles; nanoparticle shape; tumor homing; tissue penetration; potato virus X; cowpea mosaic virus; tumor xenografts
Funding
- NIH/NIBIB [R00 EB009105, P30 EB011317, T32 EB007509]
- Mt. Sinai Foundation
- Prostate Cancer Canada Grant [2011-742]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [T32EB007509, R00EB009105, P30EB011317] Funding Source: NIH RePORTER
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Nanomaterials with elongated architectures have been shown to possess differential tumor homing properties compared to their spherical counterparts. Here, we investigate whether this phenomenon is mirrored by plant viral nanoparticles that are filamentous (Potato virus X) or spherical (Cowpea mosaic virus). Our studies demonstrate that Potato virus X (PVX) and Cowpea mosaic virus (CPMV) show distinct biodistribution profiles and differ in their tumor homing and penetration efficiency. Analogous to what is seen with inorganic nanomaterials, PVX shows enhanced tumor homing and tissue penetration. Human tumor xenografts exhibit higher uptake of PEGylated filamentous PVX compared to CPMV, particularly in the core of the tumor. This is supported by immunohistochemical analysis of the tumor sections, which indicates greater penetration and accumulation of PVX within the tumor tissues. The enhanced tumor homing and retention properties of PVX along with its higher payload carrying capacity make it a potentially superior platform for applications in cancer drug delivery and imaging applications.
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