Journal
MOLECULAR PHARMACEUTICS
Volume 6, Issue 5, Pages 1544-1552Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mp900105q
Keywords
Synthetic virus; DNA condensation; RGD peptide; integrin; gene delivery; transfection
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Progress in the design of gene delivery systems is of utmost importance for cancer gene therapy since several physiological and intracellular barriers remain. We previously developed a technology for condensing a single gene into a single and stable globular nanometric system. In this manuscript, we have decorated the nanometric particles with cyclic RGD ligands in order to target endothelial cells. The potential of these artificial viruses as targeted gene delivery vehicles is demonstrated in vitro with alpha(v)beta(3) integrin-expressing primary endothelial cells.
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