Journal
MOLECULAR PHARMACEUTICS
Volume 5, Issue 2, Pages 358-363Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mp700144t
Keywords
anticancer drug; cisplatin; cyclodextrin; nanoencapsulation; platinum(II)
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A novel, water-soluble trans-platinum complex was synthesized by inclusion complexation with beta-cyclodextrin. The complexation was confirmed by H-1 NMR, FTIR, TGA, and XRD as well as by SEM and EDX. As the precursor complex is not water-soluble, it is difficult to employ it for biological applications. Here, we report that the encapsulation with cyclodextrin allowed to solubilize the complex to a solubility value of 1.6 mg/mL. Moreover, the cytotoxicity in vitro of the novel inclusion complex indicated a much higher activity after encapsulation.
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