Related references
Note: Only part of the references are listed.Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
Michael A. Jacobetz et al.
GUT (2013)
Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
Paolo P. Provenzano et al.
CANCER CELL (2012)
Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma
Janel L. Kopp et al.
CANCER CELL (2012)
Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer
Lauren J. Bayne et al.
CANCER CELL (2012)
Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia
Yuliya Pylayeva-Gupta et al.
CANCER CELL (2012)
EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma
Carolina Navas et al.
CANCER CELL (2012)
EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis
Christine M. Ardito et al.
CANCER CELL (2012)
Genetically Engineered Mouse Models of Pancreatic Cancer
Christoph Benedikt Westphalen et al.
CANCER JOURNAL (2012)
β-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice
Matthew D. Keefe et al.
DISEASE MODELS & MECHANISMS (2012)
Bmi1 Is Required for Regeneration of the Exocrine Pancreas in Mice
Akihisa Fukuda et al.
GASTROENTEROLOGY (2012)
What We Have Learned About Pancreatic Cancer From Mouse Models
Pedro A. Perez-Mancera et al.
GASTROENTEROLOGY (2012)
Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice
Aarthi Gopinathan et al.
GUT (2012)
Genetically engineered mouse models of pancreatic cancer: unravelling tumour biology and progressing translational oncology
Pawel K. Mazur et al.
GUT (2012)
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
Meredith A. Collins et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma
Natalie Cook et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Dangerous liaisons: Pancreatic stellate cells and pancreatic cancer cells
Minoti V. Apte et al.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2012)
Inhibition of the Hedgehog Pathway Targets the Tumor-Associated Stroma in Pancreatic Cancer
Rosa F. Hwang et al.
MOLECULAR CANCER RESEARCH (2012)
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
Pedro A. Perez-Mancera et al.
NATURE (2012)
nab-Paclitaxel Potentiates Gemcitabine Activity by Reducing Cytidine Deaminase Levels in a Mouse Model of Pancreatic Cancer
Kristopher K. Frese et al.
CANCER DISCOVERY (2012)
A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma
Eric A. Collisson et al.
CANCER DISCOVERY (2012)
The Expression and Clinical Significance of pSTAT3, VEGF and VEGF-C in Pancreatic Adenocarcinoma
C. Huang et al.
NEOPLASMA (2012)
Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence
Carmen Guerra et al.
CANCER CELL (2011)
Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression
Akihisa Fukuda et al.
CANCER CELL (2011)
Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer
Marina Lesina et al.
CANCER CELL (2011)
Aspirin, Nonsteroidal Anti-inflammatory Drugs, Acetaminophen, and Pancreatic Cancer Risk: a Clinic-Based Case-Control Study
Xiang-Lin Tan et al.
CANCER PREVENTION RESEARCH (2011)
STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis
Ryan B. Corcoran et al.
CANCER RESEARCH (2011)
Inactivation of Brca2 Promotes Trp53-Associated but Inhibits KrasG12D-Dependent Pancreatic Cancer Development in Mice
Matthew Rowley et al.
GASTROENTEROLOGY (2011)
Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma
Hideaki Ijichi et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Gemcitabine Plus nab-Paclitaxel Is an Active Regimen in Patients With Advanced Pancreatic Cancer: A Phase I/II Trial
Daniel D. Von Hoff et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials
Peter M. Rothwell et al.
LANCET (2011)
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
Kenichiro Furuyama et al.
NATURE GENETICS (2011)
Oncogenic Ras/Src cooperativity in pancreatic neoplasia
D. J. Shields et al.
ONCOGENE (2011)
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
Jian Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans
Gregory L. Beatty et al.
SCIENCE (2011)
Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development
Jian Wu et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB-Cytokine Network
Haoqiang Ying et al.
CANCER DISCOVERY (2011)
Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas
Toru Furukawa et al.
SCIENTIFIC REPORTS (2011)
Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection
Sara Raimondi et al.
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2010)
Non-steroidal anti-inflammatory drugs and pancreatic cancer risk: a nested case-control study
M. C. Bradley et al.
BRITISH JOURNAL OF CANCER (2010)
Germline Brca2 Heterozygosity Promotes KrasG12D -Driven Carcinogenesis in a Murine Model of Familial Pancreatic Cancer
Ferdinandos Skoulidis et al.
CANCER CELL (2010)
Notch1 Functions as a Tumor Suppressor in a Model of K-ras-Induced Pancreatic Ductal Adenocarcinoma
Linda Hanlon et al.
CANCER RESEARCH (2010)
Aspirin use and pancreatic cancer risk
Martina Bonifazi et al.
EUROPEAN JOURNAL OF CANCER PREVENTION (2010)
LKB1 Haploinsufficiency Cooperates With Kras to Promote Pancreatic Cancer Through Suppression of p21-Dependent Growth Arrest
Jennifer P. Morton et al.
GASTROENTEROLOGY (2010)
β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
John P. Morris et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
Martin Schwickart et al.
NATURE (2010)
The patterns and dynamics of genomic instability in metastatic pancreatic cancer
Peter J. Campbell et al.
NATURE (2010)
Pancreatic Cancer
Manuel Hidalgo
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas
Meritxell Rovira et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma
Pawel K. Mazur et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein-α
Matthew Kraman et al.
SCIENCE (2010)
Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras
Sharon Y. Gidekel Friedlander et al.
CANCER CELL (2009)
Inhibition of γ-Secretase Activity Inhibits Tumor Progression in a Mouse Model of Pancreatic Ductal Adenocarcinoma
Ruben Plentz et al.
GASTROENTEROLOGY (2009)
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
Olivier Nolan-Stevaux et al.
GENES & DEVELOPMENT (2009)
KRAS2 Mutations in Human Pancreatic Acinar-Ductal Metaplastic Lesions Are Limited to Those with PanIN: Implications for the Human Pancreatic Cancer Cell of Origin
Chanjuan Shi et al.
MOLECULAR CANCER RESEARCH (2009)
Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis
Eugenio Sangiorgi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive et al.
SCIENCE (2009)
Inactivation of TIF1γ Cooperates with KrasG12D to Induce Cystic Tumors of the Pancreas
David F. Vincent et al.
PLOS GENETICS (2009)
Cancer-associated stroma fibroblasts promote pancreatic tumor progression
Rosa F. Hwang et al.
CANCER RESEARCH (2008)
Hedgehog signaling is required for effective regeneration of exocrine pancreas
Volker Fendrich et al.
GASTROENTEROLOGY (2008)
Notch signaling is required for exocrine regeneration after acute pancreatitis
Jens T. Sivere et al.
GASTROENTEROLOGY (2008)
Expression patterns of epiplakin1 in pancreas, pancreatic cancer and regenerating pancreas
Tetsu Yoshida et al.
GENES TO CELLS (2008)
Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer
G. Feldmann et al.
GUT (2008)
A paracrine requirement for hedgehog signalling in cancer
Robert L. Yauch et al.
NATURE (2008)
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
Christos S. Karapetis et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
De La O. Jean-Paul et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
Nils Habbe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
Sian Jones et al.
SCIENCE (2008)
Concomitant pancreatic activation of KrasG12D and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN
Jens T. Siveke et al.
CANCER CELL (2007)
Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia
Liqin Zhu et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada clinical trials group
Malcolm J. Moore et al.
JOURNAL OF CLINICAL ONCOLOGY (2007)
The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia
Catherine Carriere et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinorna by k-Ras Oncogenes in adult mice
Carmen Guerra et al.
CANCER CELL (2007)
KrasG12D and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas
Kamel Izeradjene et al.
CANCER CELL (2007)
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-β signaling in cooperation with active Kras expression
Hideaki Ijichi et al.
GENES & DEVELOPMENT (2006)
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
Nabeel Bardeesy et al.
GENES & DEVELOPMENT (2006)
Hedgehog/Ras interactions regulate early stages of pancreatic cancer
Marina Pasca di Magliano et al.
GENES & DEVELOPMENT (2006)
Albumin-bound paclitaxel: a next-generation taxane
William J. Gradishar
EXPERT OPINION ON PHARMACOTHERAPY (2006)
Pancreatic fibrosis associated with age and ductal papillary hyperplasia
S Detlefsen et al.
VIRCHOWS ARCHIV (2005)
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas
BZ Stanger et al.
CANCER CELL (2005)
Trp53R172H and KraSG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
SR Hingorani et al.
CANCER CELL (2005)
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
H Shigematsu et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2005)
Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of hedgehog signaling on pancreatic ductal epithelial cells
NB Prasad et al.
CANCER RESEARCH (2005)
Precursors to invasive pancreatic cancer
A Maitra et al.
ADVANCES IN ANATOMIC PATHOLOGY (2005)
Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration
JN Jensen et al.
GASTROENTEROLOGY (2005)
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
AJ Aguirre et al.
GENES & DEVELOPMENT (2003)
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
SR Hingorani et al.
CANCER CELL (2003)
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
SP Thayer et al.
NATURE (2003)
Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis
Y Miyamoto et al.
CANCER CELL (2003)
Risk of pancreatic adenocarcinoma in chronic pancreatitis
D Malka et al.
GUT (2002)
Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia
NT van Heek et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease
M Wagner et al.
GENES & DEVELOPMENT (2001)