4.7 Review

Omics and therapy - A basis for precision medicine

Related references

Note: Only part of the references are listed.
Review Cell Biology

Using genetically engineered mouse models to validate candidate cancer genes and test new therapeutic approaches

Martine H. van Miltenburg et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2012)

Article Biochemical Research Methods

A pipeline for the generation of shRNA transgenic mice

Lukas E. Dow et al.

NATURE PROTOCOLS (2012)

Article Multidisciplinary Sciences

A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis

Jessica D. Kessler et al.

SCIENCE (2012)

Review Oncology

Deconstructing the molecular portraits of breast cancer

Aleix Prat et al.

MOLECULAR ONCOLOGY (2011)

Article Multidisciplinary Sciences

Integrated genomic analyses of ovarian carcinoma

D. Bell et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways

Siyuan Zhang et al.

NATURE MEDICINE (2011)

Article Biochemistry & Molecular Biology

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

Eric A. Collisson et al.

NATURE MEDICINE (2011)

Review Biochemistry & Molecular Biology

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

Mina J. Bissell et al.

NATURE MEDICINE (2011)

Article Biochemical Research Methods

A public genome-scale lentiviral expression library of human ORFs

Xiaoping Yang et al.

NATURE METHODS (2011)

Article Biotechnology & Applied Microbiology

Crizotinib

Alice T. Shaw et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

Article Medicine, General & Internal

Iniparib plus Chemotherapy in Metastatic Triple-Negative Breast Cancer.

Joyce O'Shaughnessy et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Biochemistry & Molecular Biology

Pathway Commons, a web resource for biological pathway data

Ethan G. Cerami et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Multidisciplinary Sciences

Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells

Hiroyuki Konishi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers

Akash Kumar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Cell Biology

Differential Inhibitor Sensitivity of Anaplastic Lymphoma Kinase Variants Found in Neuroblastoma

Scott C. Bresler et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

Article Biochemical Research Methods

Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM

Charles J. Vaske et al.

BIOINFORMATICS (2010)

Article Oncology

Integrative Genomic Profiling of Human Prostate Cancer

Barry S. Taylor et al.

CANCER CELL (2010)

Review Biochemistry & Molecular Biology

Macrophage Diversity Enhances Tumor Progression and Metastasis

Bin-Zhi Qian et al.

Review Pharmacology & Pharmacy

A review of erlotinib - an oral, selective epidermal growth factor receptor tyrosine kinase inhibitor

Renuka Iyer et al.

EXPERT OPINION ON PHARMACOTHERAPY (2010)

Review Genetics & Heredity

APPLICATIONS OF NEXT-GENERATION SEQUENCING Sequencing technologies - the next generation

Michael L. Metzker

NATURE REVIEWS GENETICS (2010)

Article Multidisciplinary Sciences

Automated Network Analysis Identifies Core Pathways in Glioblastoma

Ethan Cerami et al.

PLOS ONE (2010)

Article Multidisciplinary Sciences

Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing

Tom Walsh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer

Sherene Loi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Oncology

Novel Agents on the Horizon for Cancer Therapy

Wen W. Ma et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2009)

Article Oncology

PIK3CA Mutation Associates with Improved Outcome in Breast Cancer

Kevin Kalinsky et al.

CLINICAL CANCER RESEARCH (2009)

Review Oncology

Resistance to Trastuzumab in Breast Cancer

Paula R. Pohlmann et al.

CLINICAL CANCER RESEARCH (2009)

Article Medicine, General & Internal

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers.

Peter C. Fong et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Multidisciplinary Sciences

Knockin of mutant PIK3CA activates multiple oncogenic pathways

John P. Gustin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Oncology

Targeting cancer with small molecule kinase inhibitors

Jianming Zhang et al.

NATURE REVIEWS CANCER (2009)

Review Multidisciplinary Sciences

Enabling personalized cancer medicine through analysis of gene-expression patterns

Laura J. van 't Veer et al.

NATURE (2008)

Review Oncology

Lapatinib: A sword with two edges

Laszlo Kopper

PATHOLOGY & ONCOLOGY RESEARCH (2008)

Article Multidisciplinary Sciences

Tamoxifen-stimulated growth of breast cancer due to p21 loss

Abde M. Abukhdeir et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Medicine, General & Internal

Drug therapy: Trastuzumab - Mechanism of action and use in clinical practice

Clifford A. Hudis

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Article Medicine, General & Internal

Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

Brian J. Druker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Review Biotechnology & Applied Microbiology

Discovery and development of sorafenib: a multikinase inhibitor for treating cancer

Scott Wilhelm et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Article Biochemical Research Methods

Genome-scale loss-of-function screening with a lentiviral RNAi library

David E. Root et al.

NATURE METHODS (2006)

Article Medicine, Research & Experimental

Targeting tumor-associated macrophages as a novel strategy against breast cancer

Yunping Luo et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Medicine, General & Internal

Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL

Hagop Kantarjian et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Multidisciplinary Sciences

A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer

Wenle Xia et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Pharmacology & Pharmacy

Sunitinib malate for the treatment of solid tumours: a review of current clinical data

Robert J. Motzer et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2006)

Article Biochemical Research Methods

ARACNE: An algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context

AA Margolin et al.

BMC BIOINFORMATICS (2006)

Review Biochemistry & Molecular Biology

Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis

J Condeelis et al.

Article Multidisciplinary Sciences

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

H Farmer et al.

NATURE (2005)

Article Multidisciplinary Sciences

Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance

MR Burgess et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemical Research Methods

Development of Herceptin resistance in breast cancer cells

T Kute et al.

CYTOMETRY PART A (2004)

Review Biochemistry & Molecular Biology

Cancer genes and the pathways they control

B Vogelstein et al.

NATURE MEDICINE (2004)

Article Biochemistry & Molecular Biology

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

KP Olive et al.

Article Multidisciplinary Sciences

An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues

CG Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Medicine, General & Internal

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

GD Demetri et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

Article Multidisciplinary Sciences

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

T Sorlie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Medicine, General & Internal

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.

BJ Druker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

Article Medicine, General & Internal

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

DJ Slamon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

Review Biochemistry & Molecular Biology

The hallmarks of cancer

D Hanahan et al.

Article Medicine, Research & Experimental

Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia

BJ Druker et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)