Journal
MOLECULAR ONCOLOGY
Volume 5, Issue 4, Pages 308-314Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molonc.2011.05.002
Keywords
Genomic deletions; Copy number changes; DNA replication stress; Common fragile sites; Large genes
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Funding
- European FP7 Project GENICA
- Swiss National Foundation
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Human cancers are characterized by the presence of genomic instability. Recently, two studies have catalogued the presence of a specific class of genomic aberrations, large deletions and insertions, in a few thousand human cancers and reported that most of the prevalent recurrent focal deletions targeted common fragile sites and large genes. In various experimental systems, deletions in common fragile sites and large genes have been linked to the presence of DNA replication stress. Thus, taken together, these results suggest the presence of DNA replication stress in human cancers, consistent with the recently proposed oncogene-induced DNA damage model for cancer development. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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