Journal
MOLECULAR ONCOLOGY
Volume 4, Issue 5, Pages 385-396Publisher
WILEY
DOI: 10.1016/j.molonc.2010.06.009
Keywords
Prostate cancer; Cancer-initiation; Stem cell; Tissue-regeneration; Castration-resistance
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Funding
- Institutional Ruth L. Kirschstein National Research Service Award
- Prostate Cancer Foundation
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007185] Funding Source: NIH RePORTER
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Tissue stem cells have been linked to cancers of epithelial origin including the prostate. There are three relevant issues concerning stem cells and cancer that rely solely on functional studies: 1. Are there tissue-regenerating stem cells in the adult organ? 2. Can tissue-regenerating cells serve as targets for transformation? 3. Do primary tumors contain tumor-propagating (cancer stem) cells? We will review the recent literature with respect to these critical issues to provide a direct link between primitive cells and prostate cancer. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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