Journal
MOLECULAR ONCOLOGY
Volume 2, Issue 3, Pages 250-260Publisher
WILEY
DOI: 10.1016/j.molonc.2008.07.001
Keywords
Ovarian cancer; Human kallikreins; Chromosomal rearrangements
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Funding
- Ontario Cancer Biomarker Network
- Ontario Institute for Cancer Research
- Ontario Ministry of Research and Innovation
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The tissue kallikrein (KLK) genes are a new source for biomarkers in ovarian cancer. However, there has been no systematic analysis of copy number and structural rearrangements related to their protein expression. Chromosomal rearrangements and copy number changes of the KLK region were studied by FISH with protein levels measured by ELISA. Ovarian cancer and cell lines revealed the KLK region was subject to copy number imbalances or involved in unbalanced translocations and were associated with increased protein expression of KLKs 5, 6, 7, 8, 9, 10 and 11. in this initial study, we introduce the potential for long-range chromosomal effects and copy number as a mechanism for the previously reported aberrant expression of many KLK genes in ovarian cancers. (C) 2008 Federation of European Biochemical Societies Published by Elsevier B.V. All rights reserved
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