Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 59, Issue 2, Pages 323-333Publisher
WILEY
DOI: 10.1002/mnfr.201400270
Keywords
Cardiometabolic risk; Endothelial function; Inflammation; Isoflavone; Soy
Categories
Funding
- USDA Agricultural Research Service (CRIS) [CA-D*NTR-6316-H]
- University of California, Davis Henry A. Jastro Research Awards [GGNBEJ1, GGNBEJ2]
- University of California, Davis Humanities Research Award [FMSEJGS]
- NIH [P30 CA71789, S10 RR020890]
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Scope: Systemic inflammation, endothelial dysfunction, and oxidative stress are involved in the pathogenesis of the metabolic syndrome (MetS). Epidemiological evidence supports an association between whole soy food consumption and reduced risk of cardiovascular disease (CVD). The objective of this randomized, controlled, cross-over study was to evaluate the effects of soy nut consumption on inflammatory biomarkers and endothelial function and to assess whether isoflavone metabolism to secondary products, equol, and/or O-desmethylangolensin (ODMA), modifies these responses. Methods and results: n = 17 adults at cardiometabolic risk were randomly assigned to the order of two snack interventions, soy nuts, and macronutrient-matched control snack, for four weeks each, separated by a two week washout period. Outcome measures included biomarkers of inflammation, oxidative stress, and glycemic control (ELISA and clinical analyzers), endothelial function, and arterial stiffness (peripheral arterial tonometry (PAT)), and isoflavone metabolites (LC-MS/MS). Results revealed that consuming soy nuts improved arterial stiffness as assessed by the augmentation index using PAT (p = 0.03), despite lack of improvement in inflammatory biomarkers. Addition of equol and/or ODMA production status as covariates did not significantly change these results. Conclusion: Soy nuts when added to a usual diet for one month provide some benefit on arterial stiffness in adults at cardiometabolic risk.
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