Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 57, Issue 12, Pages 2253-2257Publisher
WILEY-BLACKWELL
DOI: 10.1002/mnfr.201300146
Keywords
Epithelium; Grape seed extract; Inflammatory bowel disease; Intestine; IL-10; Microbiota
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Funding
- USDA-AFRI [2009-65203-05716]
- Washington State University
- [NIHR15HD073864]
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Grape seed extract (GSE) is a by-product of the wine industry, with abundant polyphenolic compounds known for their anti-inflammatory and anti-oxidative effects. Using IL10-deficient mice (IL10KO), here we showed that GSE (1% of dry feed weight) ameliorated inflammatory bowel disease indices, increased colonic goblet cell numbers and decreased myeloperoxidase levels in the large intestine. Concomitantly, GSE supplementation attenuated inflammation, decreased the expression of pore forming tight junction protein claudin2, and increased levels of Lactobacilli and Bacteroides in the gut microbiota of IL10KO mice. In summary, our study shows that GSE has protective roles on inflammatory bowel disease through altering gut inflammation, tight junction protein expression, and gut microbiota composition.
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