Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 57, Issue 9, Pages 1557-1568Publisher
WILEY
DOI: 10.1002/mnfr.201200718
Keywords
Anti-inflammation; Antioxidative; Curcumin; Epigenetics; Retinal diseases
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Funding
- National Basic Research Program of China [2009BC918304, 2012CB524901]
- Natural Science Foundation of China [81222043, 30970607, 81172971, 81100687, 31271370]
- Program for New Century Excellent Talents in University [NECT10-0623, NECT11-0170]
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Curcumin, the major extraction of turmeric, has been widely used in many countries for centuries both as a spice and as a medicine. In the last decade, researchers have found the beneficial effects of curcumin on multiple disorders are due to its antioxidative, anti-inflammatory, and antiproliferative properties, as well as its novel function as an inhibitor of histone aectyltransferases. In this review, we summarize the recent progress made on studying the beneficial effects of curcumin on multiple retinal diseases, including diabetic retinopathy, glaucoma, and age-related macular degeneration. Recent clinical trials on the effectiveness of phosphatidylcholine formulated curcumin in treating eye diseases have also shown promising results, making curcumin a potent therapeutic drug candidate for inflammatory and degenerative retinal and eye diseases.
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