Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 58, Issue 1, Pages 211-215Publisher
WILEY-BLACKWELL
DOI: 10.1002/mnfr.201300282
Keywords
Artichoke; Cynara scolymus; Glutathione (GSH); Malondialdehyde (MDA); 8-Hydroxydeoxyguanosine (8-OHdG)
Categories
Funding
- Fund for Scientific Research (FWO-Flanders, Belgium)
Ask authors/readers for more resources
The in vivo antioxidant activity of a quantified leaf extract of Cynara scolymus (artichoke) was studied. The aqueous artichoke leaf extract (ALE), containing 1.5% caffeoylquinic acid with chlorogenic acid being most abundant (0.30%), and luteolin-7-O-glucoside as major flavonoid (0.15%), was investigated by evaluating the effect on different oxidative stress biomarkers, after 3 wk oral supplementation in the streptozotocin-induced diabetic rat model. Apart from two test groups (0.2 g Lambda LE/kg BW/day and 1 g Lambda LE/kg BW/day, where BW is body weight), a healthy control group, untreated oxidative stress group, and vitamin E treated group (positive control) were included. A 0.2 g/kg BW/day of ALE decreased oxidative stress: malondialdehyde and 8-hydroxydeoxyguanosine levels significantly diminished, whereas erythrocyte glutathione levels significantly increased. A 1.0 g/kg BW/day ALE did not show higher antioxidant activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available