Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 56, Issue 1, Pages 116-125Publisher
WILEY
DOI: 10.1002/mnfr.201100524
Keywords
DNA methylation; Hepatocarcinogenesis; Histone methylation; Methyl-deficient diet; MicroRNA
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A chronic deficiency of major dietary methyl group donors methionine, choline, folic acid, and vitamin B12 can induce the development of liver cancer in rodents. Feeding methyl-deficient diets causes several molecular alterations, including altered lipid metabolism, oxidative stress, deregulated one-carbon metabolism, and a number of epigenetic abnormalities that result in progressive liver injury culminating in the development of primary liver tumors. Importantly, this methyl-deficient model of endogenous hepatocarcinogenesis is one of the most relevant models of human liver carcinogenesis that allows studying liver cancer pathogenesis by substantially complementing many shortcomings of humans-only studies. In this review, we describe molecular changes and their role in pathogenesis of liver carcinogenesis induced by methyl deficiency.
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