Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 55, Issue 5, Pages 798-802Publisher
WILEY
DOI: 10.1002/mnfr.201100115
Keywords
Antioxidative; Coffee; Chemoprevention; Gene transcription; Nrf2 pathway
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Funding
- Federal Ministry of Education and Research (BMBF) [0313843]
- Tchibo GmbH, Germany
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Recently, the coffee constituents 5-O-caffeoylquinic acid (CGA) and N-methylpyridinium (NMP) were identified as inducers of the Nrf2/antioxidant-response element (ARE) detoxifying pathway under cell-culture condition. To study the impact of CGA and NMP on the Nrf2-activating properties of a complex coffee beverage, two different model coffees were generated by variation of the roasting conditions: a low-roast coffee rich in CGA and a heavy-roast low in CGA but containing high levels of NMP. Activation of the Nrf2/antioxidant-response element pathway was monitored in vitro and in vivo.
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