Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 54, Issue -, Pages S284-S294Publisher
WILEY
DOI: 10.1002/mnfr.200900519
Keywords
8-prenylnaringenin; 17 beta-estradiol; Bioavailability; Breast tissue; Humulus lupulus
Categories
Funding
- Office of Dietary Supplements [P50AT00155]
- National Institute of General Medicinal Sciences
- Office for Research on Women's Health
- National Center for Complementary and Alternative Medicine
- Metagenics Europe (Ostend, Belgium)
- Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen)
Ask authors/readers for more resources
Hop-derived products may contain xanthohumol (XN), isoxanthohumol (IX), and the potent phytoestrogen 8-prenylnaringenin (8-PN). To evaluate the potential health effects of these prenylflavonoids on breast tissue, their concentration, nature of metabolites, and biodistribution were assessed and compared with 17 beta-estradiol (E-2) exposure. In this dietary intervention study, women were randomly allocated to hop (n = 11; 2.04 mg XN, 1.20 mg IX, and 0.1 mg 8-PN per supplement) or control (n = 10). After a run-in of >= 4 days, three supplements were taken daily for 5 days preceding an aesthetic breast reduction. Blood and breast biopsies were analyzed using HPLC-ESI-MS/MS. Upon hop administration, XN and IX concentrations ranged between 0.72 and 17.65 nmol/L and 3.30 and 31.50 nmol/L, and between 0.26 and 5.14 pmol/g and 1.16 and 83.67 pmol/g in hydrolyzed serum and breast tissue, respectively. 8-PN however, was only detected in samples of moderate and strong 8-PN producers (0.43-7.06 nmol/L and 0.78-4.83 pmol/g). Phase I metabolism appeared to be minor (similar to 10%), whereas extensive glucuronidation was observed (> 90%). Total prenylflavonoids showed a breast adipose/glandular tissue distribution of 38/62 and their derived E-2-equivalents were negligible compared with E-2 in adipose (384.6 +/- 118.8 fmol/g, p = 0.009) and glandular (241.6 +/- 93.1 fmol/g, p<0.001) tissue, respectively. Consequently, low doses of prenylflavonoids are unlikely to elicit estrogenic responses in breast tissue.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available