4.7 Article

A Mediterranean diet rich in virgin olive oil may reverse the effects of the-174G/C IL6 gene variant on 3-year body weight change

Journal

MOLECULAR NUTRITION & FOOD RESEARCH
Volume 54, Issue -, Pages S75-S82

Publisher

WILEY
DOI: 10.1002/mnfr.200900257

Keywords

Body weight change; IL6 polymorphism; Mediterranean diet; Nutritional intervention; PREDIMED

Funding

  1. Department of Health of the Navarra Government (Spain)
  2. Linea Especial University of Navarra [LE 97]
  3. Spanish Ministry of Health [RD 06/0045/0000]
  4. ISCIII [CB06/03/1017]
  5. IBERCAJA

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Only a few studies have analyzed the effects of the potential interaction between the -174G/C polymorphism of IL6 gene and the adherence to the Mediterranean diet (MD) on adiposity indexes. Our aim was to investigate the interplay between the -174G/C polymorphism of the IL6 gene and a Mediterranean-style diet on body weight changes after 3 years of nutritional intervention in a high cardiovascular risk population. A total of 737 participants, aged 55-80 years were assigned to a low-fat diet or to a Mediterranean-style diet group with high intake of virgin olive oil (VOO) or nuts. Anthropometric measurements were taken at baseline and after 3-year follow-up. The -174G/C polymorphism of the IL6 gene was genotyped. Minor allele frequency (C) was 0.39. At baseline, the CC genotype was associated with higher measures of adiposity. After 3 years, a significant interaction (p = 0.028) was found between the polymorphism (GG+GC versus CC) and the nutritional intervention: CC subjects following the MD+VOO had the lowest body weight gain. In conclusion, at baseline, CC subjects for the -174G/C polymorphism of IL6 had the highest body weight and BMI. However, after 3 years of nutritional intervention with MD+VOO, these subjects were predicted to have the greatest reduction in body weight.

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