Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 53, Issue 1, Pages 29-48Publisher
WILEY
DOI: 10.1002/mnfr.200700470
Keywords
Anticancer drugs; Glycolysis; Mitochondria; Oxidative phosphorylation
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Funding
- CONA-CYT-Mexico [Salud-2002-C01-7677, 80534, SEP-4671-Q, SEP-2007-60517]
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The main purpose of this review is to update and analyze the effect of several antineoplastic drugs (adriamycin, apoptodilin, casiopeinas, cisplatin, clotrimazole, cyclophosphamide, ditercalinium, NSAIDs, tamoxifen, taxol, 6-mercaptopurine, and alpha-tocopheryl succinate) and energy metabolism inhibitors (2-DOG, gossypol, delocalized lipophilic cations, and uncouplers) oil tumor development and progression, The possibility that these antineoplastic drugs Currently used in in vitro cancer models, in chemo-therapy, or under study ill phase I to III clinical trials induce tumor cellular death by altering also metabolite concentration (i.e., ATP), enzyme activities, and/or energy metabolism fluxes is assessed. It is proposed that the use of energy metabolic therapy, as an alternative or complementary strategy, might be a promising novel approach in the treatment of cancer.
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