Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 53, Issue 7, Pages 897-903Publisher
WILEY
DOI: 10.1002/mnfr.200800269
Keywords
Colon cancer; Hydroxytyrosol; MAPK kinase; Olive oil; Polyphenol
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Funding
- Biotechnology and Biological Sciences Research Council [BB/C518222/1, BB/F008953/1, BB/G005702/1]
- Medical Research Council [G0400278/N102]
- Biotechnology and Biological Sciences Research Council [BB/F008953/1, BB/G005702/1, BB/C518222/1] Funding Source: researchfish
- BBSRC [BB/F008953/1, BB/G005702/1] Funding Source: UKRI
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Extra virgin olive oil is rich in phenolic compounds which are believed to exert beneficial effects against many pathological processes, including the development of colon cancer. We show that one of the major polyphenolic constituents of extra virgin olive oil, hydroxytyrosol (HT), exerts strong anti-proliferative effects against human colon adenocarcinoma cells via its ability to induce a cell cycle block in G2/M. These antiproliferative effects were preceded by a strong inhibition of extracellular signal-regulated kinase (ERK) 1/2 phosphorylation and a downstream reduction of cyclin D I expression, rather than by inhibition of p38 activity and cyclooxygenase-2 (COX-2) expression. These findings are of particular relevance due to the high colonic concentration of HT compared to the other olive oil polyphenols and may help explain the inverse link between colon cancer and olive oil consumption.
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