Journal
MOLECULAR NEUROBIOLOGY
Volume 49, Issue 3, Pages 1422-1434Publisher
SPRINGER
DOI: 10.1007/s12035-013-8620-6
Keywords
Microglia; Phagocytosis; Neurological diseases; Macrophages
Categories
Funding
- National Natural Science Foundation of China [81272576, 81072242]
- Fundamental Research Funds for the Central Universities
- Funds for Pearl River Science & Technology Star of Guangzhou City [2012J2200088]
Ask authors/readers for more resources
Microglia, the resident macrophages of the central nervous system, rapidly activate in nearly all kinds of neurological diseases. These activated microglia become highly motile, secreting inflammatory cytokines, migrating to the lesion area, and phagocytosing cell debris or damaged neurons. During the past decades, the secretory property and chemotaxis of microglia have been well-studied, while relatively less attention has been paid to microglial phagocytosis. So far there is no obvious concordance with whether it is beneficial or detrimental in tissue repair. This review focuses on phagocytic phenotype of microglia in neurological diseases such as Alzheimer's disease, multiple sclerosis, Parkinson's disease, traumatic brain injury, ischemic and other brain diseases. Microglial morphological characteristics, involved receptors and signaling pathways, distribution variation along with time and space changes, and environmental factors that affecting phagocytic function in each disease are reviewed. Moreover, a comparison of contributions between macrophages from peripheral circulation and the resident microglia to these pathogenic processes will also be discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available