Journal
SCIENCE TRANSLATIONAL MEDICINE
Volume 7, Issue 283, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.3009367
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Funding
- Intramural Research Program of NIH
- National Cancer Institute
- NATIONAL CANCER INSTITUTE [ZIABC010830, ZIABC011559] Funding Source: NIH RePORTER
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The mechanisms underlying the spatiotemporal evolution of tumor ecosystems present a challenge in evaluating drug efficacy. In this Perspective, we address the use of three-dimensional in vitro culture models to delineate the dynamic interplay between the tumor and the host microenvironment in an effort to attain realistic platforms for assessing pharmaceutical efficacy in patients.
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