Journal
MOLECULAR NEUROBIOLOGY
Volume 51, Issue 3, Pages 1343-1352Publisher
SPRINGER
DOI: 10.1007/s12035-014-8813-7
Keywords
Endoplasmic reticulum stress; Central nervous system; Neurodegeneration; Stroke; Spinal cord injury; Therapeutics
Categories
Funding
- Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents
- National Natural Science Funding of China [81372112, 81200958, 81200010, 81302775]
- Zhejiang Provincial Project of Protein Medicine Key Group [2010R50042]
Ask authors/readers for more resources
Endoplasmic reticulum (ER) stress plays an important role in a range of neurological disorders, such as neurodegenation diseases, cerebral ischemia, spinal cord injury, sclerosis, and diabetic neuropathy. Protein misfolding and accumulation in the ER lumen initiate unfolded protein response in energy-starved neurons which are relevant to toxic effects. In neurological disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, ER dysfunction is well recognized, but the mechanisms remain unclear. In stroke and ischemia, spinal cord injury, and amyotrophic lateral sclerosis, chronic activation of ER stress is considered as main pathogeny which causes neuronal disorders. By targeting components of these ER signaling responses, to explore clinical treatment strategies or new drugs in CNS neurological diseases might become possible and valuable in the future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available