Journal
MOLECULAR NEUROBIOLOGY
Volume 45, Issue 3, Pages 605-620Publisher
HUMANA PRESS INC
DOI: 10.1007/s12035-012-8278-5
Keywords
ADHD; Dopamine receptor; Meta-analysis
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Funding
- National Nature Science Foundation of China (NSFC) [81101016]
- New Century Excellent Talents in University [NCET-10-0421]
- Ministry of Science and Technology of China [2011DFG33250]
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The dopaminergic system plays a pivotal role in the central nervous system via its five diverse receptors (D1-D5). Dysfunction of dopaminergic system is implicated in many neuropsychological diseases, including attention deficit hyperactivity disorder (ADHD), a common mental disorder that prevalent in childhood. Understanding the relationship of five different dopamine (DA) receptors with ADHD will help us to elucidate different roles of these receptors and to develop therapeutic approaches of ADHD. This review summarized the ongoing research of DA receptor genes in ADHD pathogenesis and gathered the past published data with meta-analysis and revealed the high risk of DRD5, DRD2, and DRD4 polymorphisms in ADHD.
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