Journal
MOLECULAR NEUROBIOLOGY
Volume 45, Issue 2, Pages 225-233Publisher
HUMANA PRESS INC
DOI: 10.1007/s12035-012-8240-6
Keywords
Melanocortin; Leptin; Serotonin; Segregation; Insulin; Energy expenditure; Body weight; Adiposity; Hyperglycemia; TRPC; PI3K
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Funding
- American Diabetes Association [7-11-MN-16]
- National Institutes of Health [K01 DK087780]
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Arcuate nucleus (ARC) pro-opiomelanocortin (POMC) neurons are essential regulators of food intake, energy expenditure, and glucose homeostasis. POMC neurons integrate several key metabolic signals that include neurotransmitters and hormones. The change in activity of POMC neurons is relayed to melanocortin receptors in distinct regions of the central nervous system. This review will summarize the role of leptin and serotonin receptors in regulating the activity of POMC neurons and provide a model in which different melanocortin pathways regulate energy and glucose homeostasis.
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