Journal
MOLECULAR NEUROBIOLOGY
Volume 46, Issue 1, Pages 96-113Publisher
SPRINGER
DOI: 10.1007/s12035-012-8263-z
Keywords
P2Y(2) receptor; P2X7 receptor; Neuroprotection; Neuroinflammation
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Funding
- NIA NIH HHS [P01 AG018357] Funding Source: Medline
- NIDCR NIH HHS [R01 DE007389, R01 DE017591] Funding Source: Medline
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Extracellular nucleotides induce cellular responses in the central nervous system (CNS) through the activation of ionotropic P2X and metabotropic P2Y nucleotide receptors. Activation of these receptors regulates a wide range of physiological and pathological processes. In this review, we present an overview of the current literature regarding P2X and P2Y receptors in the CNS with a focus on the contribution of P2X7 and P2Y(2) receptor-mediated responses to neuroinflammatory and neuroprotective mechanisms.
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