Journal
MOLECULAR NEUROBIOLOGY
Volume 43, Issue 1, Pages 27-40Publisher
SPRINGER
DOI: 10.1007/s12035-010-8155-z
Keywords
Subarachnoid hemorrhage; Delayed vasospasm; Cerebral ischemia; Early brain injury; Therapeutic interventions
Categories
Funding
- American Heart Association [GRNT4570012]
- National Institutes of Health [RO1 NS050576, NS053407]
- Intramural Research Program
- National Institutes of Stroke and Neurological Disorders, NIH
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Delayed vasospasm that develops 3-7 days after aneurysmal subarachnoid hemorrhage (SAH) has traditionally been considered the most important determinant of delayed ischemic injury and poor outcome. Consequently, most therapies against delayed ischemic injury are directed towards reducing the incidence of vasospasm. The clinical trials based on this strategy, however, have so far claimed limited success; the incidence of vasospasm is reduced without reduction in delayed ischemic injury or improvement in the long-term outcome. This fact has shifted research interest to the early brain injury (first 72 h) evoked by SAH. In recent years, several pathological mechanisms that activate within minutes after the initial bleed and lead to early brain injury are identified. In addition, it is found that many of these mechanisms evolve with time and participate in the pathogenesis of delayed ischemic injury and poor outcome. Therefore, a therapy or therapies focused on these early mechanisms may not only prevent the early brain injury but may also help reduce the intensity of later developing neurological complications. This manuscript reviews the pathological mechanisms of early brain injury after SAH and summarizes the status of current therapies.
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