Journal
MOLECULAR NEUROBIOLOGY
Volume 41, Issue 2-3, Pages 87-96Publisher
SPRINGER
DOI: 10.1007/s12035-009-8095-7
Keywords
Alzheimer's disease; Mitochondrial dynamics; Mitochondrial fission; Mitochondrial fusion; Drug; Dimebon
Categories
Funding
- NIH [AG031852]
- Alzheimer's Association [IIRG-07-60196]
- NATIONAL INSTITUTE ON AGING [R01AG031852] Funding Source: NIH RePORTER
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Mitochondria are dynamic organelles that undergo continuous fission and fusion, which could affect all aspects of mitochondrial function. Mitochondrial dysfunction has been well documented in Alzheimer's disease (AD). In the past few years, emerging evidence indicates that an imbalance of mitochondrial dynamics is involved in the pathogenesis of AD. In this review, we discuss in detail the abnormal mitochondrial dynamics in AD and how such abnormal dynamics may impact mitochondrial and neuronal function and contribute to the course of disease. Based on this discussion, we propose that mitochondrial dynamics could be a potential therapeutic target for AD.
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