Journal
MOLECULAR NEUROBIOLOGY
Volume 40, Issue 1, Pages 73-86Publisher
SPRINGER
DOI: 10.1007/s12035-009-8072-1
Keywords
ICER; CRE-mediated gene transcription; CREB; Long-term plasticity; Epileptogenesis; Learning; Memory; cAMP; cAMP-dependent; Immediate early gene
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The inducible cAMP early repressor (ICER) is an endogenous repressor of cAMP-responsive element (CRE)-mediated gene transcription and belongs to the CRE-binding protein (CREB)/CRE modulator (CREM)/activating transcription factor 1 (ATF-1) gene family. ICER plays an important role in regulating the neuroendocrine system and the circadian rhythm. Other aspects of ICER function have recently attracted heightened attention. Being a natural inducible CREB antagonist, and more broadly, an inducible repressor of CRE-mediated gene transcription, ICER regulates long-lasting plastic changes that occur in the brain in response to incoming stimulation. This review will bring together data on ICER and its functions in the brain, with a special emphasis on recent findings highlighting the involvement of ICER in the regulation of long-term plasticity underlying learning and memory.
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