Journal
MOLECULAR MICROBIOLOGY
Volume 74, Issue 6, Pages 1380-1392Publisher
WILEY
DOI: 10.1111/j.1365-2958.2009.06934.x
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Funding
- Danish Natural Science Research Council
- Lundbeck Foundation
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P>Using flow chamber-grown Pseudomonas aeruginosa biofilms as model system, we show in the present study that formation of heterogeneous biofilms may occur through mechanisms that involve complex subpopulation interactions. One example of this phenomenon is expression of the iron-siderophore pyoverdine in one subpopulation being necessary for development of another subpopulation that does not itself express the pyoverdine synthesis genes. Another example is quorum sensing-controlled DNA release in one subpopulation being necessary for development of another subpopulation that does not itself express the quorum-sensing genes.
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