Journal
MOLECULAR MICROBIOLOGY
Volume 69, Issue 6, Pages 1341-1348Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2958.2008.06378.x
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Funding
- NIGMS NIH HHS [F32 GM020627, F32 GM020627-02] Funding Source: Medline
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It has been postulated that bacterial DNA replication occurs via a factory mechanism in which unreplicated DNA is spooled into a centrally located replisome and newly synthesized DNA is discharged towards opposite cell poles. Although there is considerable support for this view, it does not fit with many key observations. I review new findings, and provide alternative interpretations for old findings, which challenge this model. As a whole, current data suggest that the replisome, at least in slowly growing Escherichia coli cells, tracks along a stationary chromosome. These replisomes are not stationary, tethered or restricted in their movement, but rather travel throughout the nucleoid. One possibility is that the replisome navigates along a chromosome made up of looped domains as has been previously envisioned.
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