Journal
MOLECULAR MEMBRANE BIOLOGY
Volume 26, Issue 1-2, Pages 104-113Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09687680802706432
Keywords
MBOAT; hedgehog; wingless; Wnt; ghrelin; palmitoylation; acylation; protein acyl transferase
Categories
Funding
- UK Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Medical Research Council [G0400710] Funding Source: researchfish
- MRC [G0400710] Funding Source: UKRI
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Members of the MBOAT family of multispanning transmembrane enzymes catalyze the acylation of important secreted signalling proteins of the Hedgehog, Wg/Wnt and ghrelin families. Acylation of these substrates occurs during transport through the secretory pathway and plays key roles in their biological activity and spread from producing cells, contributing to the formation of appropriate extracellular concentration gradients. Characterization of these enzymes could lead to their identification as therapeutic targets for diverse human diseases such as cancers, obesity and diabetes.
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