Journal
MOLECULAR MEMBRANE BIOLOGY
Volume 25, Issue 8, Pages 677-682Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09687680802552257
Keywords
Multidrug efflux protein; AcrB; bile acid; E; coli; structure
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Funding
- Biotechnology and Biological Science Research Council (BBSRC)
- Swedish Research Council
- Center of Biomembrane Research through the Swedish Foundation of Strategic Research
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Gastrointestinal bacteria, like Escherichia coli, must remove bile acid to survive in the gut. Bile acid removal in E. coli is thought to be mediated primarily by the multidrug efflux pump, AcrB. Here, we present the structure of E. coli AcrB in complex with deoxycholate at 3.85 resolution. All evidence suggests that bile acid is transported out of the cell via the periplasmic vestibule of the AcrAB-TolC complex.
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