Journal
MOLECULAR MEDICINE REPORTS
Volume 11, Issue 1, Pages 166-174Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2014.2755
Keywords
gene expression; immunomodulatory ability; senescence; umbilical cord-mesenchymal stem cell
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Funding
- Fundamental Research Funds of Shandong University [2014QY003-11]
- Shandong Province Natural Science Foundation [2013GSF11812]
- 973 Research Development Program [2012CB966504]
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Mesenchymal stem cells (MSCs) are a potential source of adult stem cells for cell-based therapeutics due to their substantial multilineage differentiation capacity and secretory functions. No information is presently available regarding the maintenance of immunosuppressive properties of this cell type with repeated passages. It was therefore the aim of the present study to analyze the biological properties, particularly the immunoregulatory effect, of MSCs from late passages. The differences between young and old MSCs in morphology, cell surface antigen phenotype, proliferation, gene expression and immunomodulatory ability were investigated. The results of the current study demonstrated that with the passage of cells, senescent MSCs displayed a characteristically enlarged and flattened morphology, different gene expression profiles and stronger immunosuppressive activities. Increased interleukin-6 production may be a possible underlying mechanism for this enhanced immunomodulatory ability of MSCs. These findings suggest that aged MSCs may provide a treatment option for patients with graft versus host disease and other diseases associated with dysregulation of the immune system.
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