Journal
MOLECULAR MEDICINE REPORTS
Volume 11, Issue 3, Pages 1669-1674Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2014.2996
Keywords
capsinoids; adipocyte; lipid metabolism; fat accumulation; liver; adipose tissue
Categories
Funding
- National Natural Science Foundation of China [81302421/H2603]
- Natural Science Foundation of Hunan Province, China [12JJ6098]
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Capsaicin, found in red peppers, has been reported to have anti-obesity, anti-hypertension, anti-diabetes and anti-inflammatory functions. In the present study, we determined the effect of non-pungent capsinoids on the metabolism of adipocytes. We demonstrated that capsinoids suppressed fat accumulation in vivo and in vitro in mice. Liver, the main tissue of lipid metabolism, was treated by capsinoids, and HMG-CoA reductase, CPT-1, FAT/CD36 and GLUT4 were found to be increased significantly, which demonstrated promotion of the lipid metabolism in liver and adipose tissues. In addition, by adding capsinoids, the induced adipocytes also demonstrated significantly increased levels of HMG-CoA reductase, CPT-1, FAT/CD36 and GLUT4. Oil red 0 staining also demonstrated that capsinoids decreased fat accumulation in the adipocytes. In conclusion, these results indicate that capsinoids may be worth investigating as a potential cure for obesity.
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