Journal
MOLECULAR MEDICINE REPORTS
Volume 8, Issue 6, Pages 1611-1616Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2013.1714
Keywords
peroxisome proliferator-activated receptors; inflammation; adipocytes; metabolic syndrome
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Funding
- CONICYT REGIONAL/GORE [MAULE/CEAP/R09I2001]
- Programa de Investigacion de Excelencia Interdisciplinaria en Envejecimiento Saludable (PIEI-ES)
- Fondecyt, Chile [1130216]
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Metabolic syndrome (MS) includes the presence of arterial hypertension, insulin resistance, dyslipidemia, cardiovascular disease (CVD) and abdominal obesity, which is associated with a chronic inflammatory response, characterized by abnormal adipokine production, and the activation of certain pro-inflammatory signaling pathways. Furthermore, the changes presented by the adipose tissue in MS favors the secretion of several molecular mediators capable of activating or suppressing a number of transcription factors, such as the peroxisome proliferator-activated receptors (PPARs), whose main functions include storage regulation and fatty acid catabolization. When they are activated by their ligands (synthetic or endogenous), they control several genes involved in intermediate metabolism, which make them, together with the PPAR gamma coactivator-1- (PGC-1) and the silent information regulator T1 (SIRT1), good targets for treating metabolic diseases and their cardiovascular complications.
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