Journal
MOLECULAR MEDICINE
Volume 16, Issue 11-12, Pages 552-557Publisher
FEINSTEIN INST MED RES
DOI: 10.2119/molmed.2010.00067
Keywords
-
Ask authors/readers for more resources
Tumor necrosis factor-alpha (TNF-alpha) is the major target of the therapeutic approach in rheumatoid arthritis, A key issue in the approach to chronic arthritis is the understanding of the crucial molecules driving the transition from the acute phase to the chronic irreversible phase of the disease. In this review we analyzed five experimental arthritis animal models (antigen-induced arthritis, adjuvant-induced arthritis, streptococcal cell wall arthritis, collagen-induced arthritis and SKG) considered as possible scenarios to facilitate interpretation of the biology of human rheumatoid arthritis. The SKG model is strictly dependent on interleukin (IL)-6. In the other models, IL-1 beta and IL-6, more than TNF-alpha, appear to be relevant in driving the transition, which suggests that these should be the targets of an early intervention to stop the course toward the chronic form of the disease. (C) 2010 The Feinstein Institute for Medical Research, www.feinsteininstitute.org
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available