Journal
MOLECULAR MEDICINE
Volume 15, Issue 9-10, Pages 352-358Publisher
FEINSTEIN INST MED RES
DOI: 10.2119/molmed.2009.00035
Keywords
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Funding
- Dana Foundation
- Burroughs Wellcome Fund
- Starr Foundation
- National Cancer Institute [R01CA108609, R01CA101741]
- National Institute of Allergy and Infectious Diseases [RFP-NIH-NIAID-DAIDS-BAA-06-19]
- Foundation for the National Institutes of Health
- Institutional Clinical and Translational Science Award
- Institutional Clinical and Translational Science Pilot and Collaborative Project Grant
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Natural killer (NK) cells were viewed traditionally as cytotoxic effector cells whose rapid killing of infected and transformed cells without preactivation provides a first line of defense prior to the initiation of an adaptive immune response against infection and tumor development. However, it has become clear that NK cells interact with various components of the immune system, and therefore have the potential to function as regulatory cells. While NK cells can assist in dendritic cell (DC) maturation and T-cell polarization, increasing evidence indicates that NK cells can also prevent and limit adaptive (auto) immune responses via killing of autologous myeloid and lymphoid cells. Investigating immunoregulatory NK-cell functions might generate exciting insights into the reciprocal regulation between NK-cell-mediated innate immunity and adaptive immune responses, improve our capacity to monitor these cells as surrogate markers for disease activity and treatment responses in autoimmune diseases, and, perhaps, provide new prospects for NK cell-directed therapies. (C) 2009 The Feinstein Institute for Medical Research, www.feinsteininstitute.org Online address: http://www.molmed.org doi: 10.2119/molmed.2009.00035
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