Journal
MOLECULAR INTERVENTIONS
Volume 10, Issue 2, Pages 98-111Publisher
AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
DOI: 10.1124/mi.10.2.7
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Funding
- Zumberge award (Office of the Provost, University of Southern California)
- National Institutes of Heath [AA016911, DK037034, DK070195, DK070844, DK073336, AA016011, ES011195, ES009047, ES016731, DK067215, DK48522]
- Pfizer, Inc.
- Helsinn Healthcare S. A.
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Mitochondria play key roles in aerobic life and in cell death. Thus, interference of normal mitochondrial function impairs cellular energy and lipid metabolism and leads to the unleashing of mediators of cell death. The role of mitochondria in cell death due to drug hepatotoxicity has been receiving renewed attention and it is therefore timely to assess the current status of this area.
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