Journal
MOLECULAR INTERVENTIONS
Volume 10, Issue 3, Pages 153-163Publisher
AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
DOI: 10.1124/mi.10.3.6
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Funding
- National Institutes of Health National Cancer Institute [R37 CA090426]
- National Institute of Environmental Health Sciences [P30 ES000267]
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With the rapid completion of genomic sequences of organisms today, we have far more gene products than functions we can ascribe. A number of experimental strategies have been developed and applied, both in vitro and in vivo, to put functions to these orphan proteins. The deorphanization of human and Streptomyces cytochrome P450 enzymes is considered quite important for pharmacology, with ramifications for the use of clinical therapeutics. The myriad of possibilities is too enormous to screen one reaction at a time, thus metabolomic or proteomic screens with complex biological samples are promising current strategies.
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