Journal
MOLECULAR IMMUNOLOGY
Volume 58, Issue 1, Pages 32-37Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2013.11.003
Keywords
Collagen; Cytokine; JNK; Macrophage; NF-kappa B; TLR4
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Funding
- Grants-in-Aid for Scientific Research [24580188] Funding Source: KAKEN
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We previously reported that jellyfish collagen stimulates both the acquired and innate immune responses. In the acquired immune response, jellyfish collagen enhanced immunoglobulin production by lymphocytes in vitro and in vivo. Meanwhile, in the innate immune response jellyfish collagen promoted cytokine production and phagocytotic activity of macrophages. The facts that jellyfish collagen plays several potential roles in stimulating cytokine production by macrophages have further attracted us to uncover its mechanisms. We herein describe that the cytokine production-stimulating activity of jellyfish collagen was canceled by a Toll-like receptor 4 (TLR4) inhibitor. Moreover, jellyfish collagen stimulated phosphorylation of inhibitor of kappa B alpha (I kappa B alpha), promoted the translocation of nucleus factor-kappa B (NF-kappa B), and activated c-Jun N-terminal kinase (JNK). A JNK inhibitor also abrogated the cytokine production-stimulating activity of jellyfish collagen. These results suggest that jellyfish collagen may facilitate cytokine production by macrophages through activation of NF-kappa B and JNK via the TLR4 signaling pathways. (C) 2013 Elsevier Ltd. All rights reserved.
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