Journal
MOLECULAR IMMUNOLOGY
Volume 57, Issue 1, Pages 12-21Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2013.06.012
Keywords
ERAPI; Aminopeptidases; Ankylosing spondylitis; HLA-B27; Spondyloarthropathies; Antigen processing
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Funding
- FundaciOn Ramon Areces to the Centro de Biologia Molecular Severo Ochoa
- Plan Nacional de I+D+i [SAF2011/25681]
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The endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme involved in the final processing of Major Histocompatibility Complex class I (MHC-I) ligands and with a significant influence in the stability and immunological properties of MHC-I proteins. ERAPI polymorphism is associated with ankylosing spondylitis among HLA-B27-positive individuals and the altered enzymatic activity of natural variants has significant effects on the HLA-B27 peptidome, suggesting a critical pathogenetic role of peptides in this disease. Likewise, the association of ERAP1 with other MHC-I associated disorders and its epistasis with their susceptibility MHC alleles point out to a general role of the MHC-I peptidome in these diseases. The functional interaction between ERAP1 and HLA-B27 or other MHC-I molecules may be related to the processing of specific epitopes, or to a more general peptide-dependent influence on other biological features of the MHC-I proteins. In addition, from a consideration of the reported functions of ERAP1, including its involvement in angiogenesis and macrophage activation, a more complex and multi-level influence in the inflammatory and immune pathways operating in these diseases cannot be ruled out. (C) 2013 Elsevier Ltd. All rights reserved.
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