Journal
MOLECULAR IMMUNOLOGY
Volume 62, Issue 2, Pages 329-338Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2013.11.013
Keywords
B cells; Lupus; Autoimmunity
Categories
Funding
- NIAID NIH HHS [R01 AI058150, T32 AI074491] Funding Source: Medline
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Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. This review summarizes first the results obtained in the mouse that have revealed how B cell tolerance is breached in SLE. We then review the B cell subsets, in addition to the autoAb producing cells, which contribute to SLE pathogenesis, focusing on marginal zone B cells, B-1 cells and regulatory B cells. Finally, we review the interactions between B cells and other immune cells that have been implicated in SLE, such as dendritic cells, macrophages, neutrophils and T cells. (C) 2013 Elsevier Ltd. All rights reserved.
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