Journal
MOLECULAR IMMUNOLOGY
Volume 48, Issue 15-16, Pages 2214-2219Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2011.06.436
Keywords
T cells; Cell activation; Costimulatory molecules; PD-L2
Categories
Funding
- Institut National de la Sante et de la Recherche Medicale
- Bourse Franco-Algerienne
- Ligue Nationale contre le Cancer
- Association pour la Recherche sur la Cancer
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T-cell activation and proliferation are regulated by cosignaling adhesion molecules involved in positive or negative signals. Programmed death (PD)-1 is one of immune inhibitory molecules that is expressed in activated T cells and is a promising target for immunotherapy. Both PD-1 ligands, PD-L1 and PD-L2 are expressed on antigen presenting cells (APCs) involved in the dialogue between a T cell and an APC. Here, we analysed the expression of these ligands, especially for PD-L2, on T cells. PD-L2 appears to be expressed on activated CD4 and CD8T cell subsets. Moreover, as PD-1 molecule, PD-L2 engagement at the surface of T cells is able to down-modulate cytokine production and cell proliferation. These observations indicate that PD-L2 is expressed following activation and is involved in the regulation of T cell function, highlighting the level of complexity in the T cell cosignaling network. (C) 2011 Elsevier Ltd. All rights reserved.
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