Journal
MOLECULAR IMMUNOLOGY
Volume 48, Issue 4, Pages 691-696Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2010.11.017
Keywords
Platelets; Immune-complexes; Fc gamma receptor; Phagocytosis; Phagocytes; Transgenic mice
Categories
Funding
- NIH [AI-22193]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI022193, R01AI022193] Funding Source: NIH RePORTER
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In addition to their primary role in hemostasis and wound healing, platelets play important roles in a multitude of physiological functions including immune and inflammatory responses. We present data that platelets, by virtue of their expression of the human specific Fc gamma R, Fc gamma RIIA, bind IgG complexes in vivo and that circulating phagocytes from healthy individuals internalize platelets in vivo. Human platelets, as a consequence of their expression of Fc gamma RIIA, may thus, contribute to the clearance of IgG-containing complexes from the circulation. (C) 2010 Elsevier Ltd. All rights reserved.
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