Journal
MOLECULAR IMMUNOLOGY
Volume 47, Issue 13, Pages 2187-2197Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2010.05.007
Keywords
Alternative pathway; Complement; Human; Factor H
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Funding
- NHLBI NIH HHS [P30 HL101317-01, P30 HL101317, 1P30HL101317-01] Funding Source: Medline
- NIDDK NIH HHS [R37 DK035081, R01 DK035081-26, R01 DK035081, DK-35081] Funding Source: Medline
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The complement system is an essential component of the innate immune system that participates in elimination of pathogens and altered host cells and comprises an essential link between the innate and adaptive immune system. Soluble and membrane-bound complement regulators protect cells and tissues from unintended complement-mediated injury. Complement factor H is a soluble complement regulator essential for controlling the alternative pathway in blood and on cell surfaces. Normal recognition of self-cell markers (i.e. polyanions) and C3b/C3d fragments is necessary for factor H function. Inadequate recognition of host cell surfaces by factor H due to mutations and polymorphisms have been associated with complement-mediated tissue damage and disease. On the other hand, unwanted recognition of pathogens and altered self-cells (i.e. cancer) by factor H is used as an immune evasion strategy. This review will focus on the current knowledge related to these versatile recognition properties of factor H. (C) 2010 Elsevier Ltd. All rights reserved.
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