Journal
MOLECULAR IMMUNOLOGY
Volume 47, Issue 1, Pages 71-78Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2008.12.018
Keywords
CD8 T cell memory; TCR-transgenic CD8 T cells; Infection; Listeria monocytogenes
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In adoptive transfer experiments, the initial frequency of naive TCR-transgenic T cells impacts CD8 T cell phenotype after acute infections. The exact reasons for the observed changes, however, are unclear and it is unknown whether alterations in phenotype translate into impaired memory T cell function as well. Here we perform in vivo comparisons of effector and memory CD8 T cells generated from high or low numbers of naive precursors. We show that high numbers of adoptively transferred T cells exhibit effector functions that alter systemic inflammation and pathogen abundance in the initial days after infection. While these altered environmental conditions resulted in profound changes in primary effector and memory CD8 T cell phenotype, memory T cells derived from both high and low numbers of naive precursors protected equally well against re-infection and generated secondary effector and memory T cells that were similar in numbers and phenotype. Our results confirm the necessity to use low numbers of naive precursors to mimic endogenous immune responses but show at the same time that memory CD8 T cell function in adoptive transfers is independent of input numbers. (C) 2008 Elsevier Ltd. All rights reserved.
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