Journal
MOLECULAR IMMUNOLOGY
Volume 45, Issue 16, Pages 4048-4056Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2008.06.034
Keywords
Properdin; Complement; Apoptosis; Phagocytosis; Neutrophils; Complement alternative pathway; Glycosaminoglycans; Pattern recognition
Categories
Funding
- Medical Research Council [G0600698B] Funding Source: researchfish
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Properdin was first described over 50 years ago by Louis Pillemer and his collaborators as a vital component of an antibody-independent complement activation pathway. In the 1970s properdin was shown to be a stabilizing component of the alternative pathway convertases, the central enzymes of the complement cascade. Recently we have reported that properdin can also bind to target cells and microbes, provide a platform for convertase assembly and function, and promote target phagocytosis. Evidence is emerging that suggests that properclin interacts with a network of target ligands, phagocyte receptors, and serum regulators. Here we review the new findings and their possible implications. (C) 2008 Elsevier Ltd. All rights reserved.
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