Journal
MOLECULAR IMMUNOLOGY
Volume 45, Issue 15, Pages 3990-3999Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2008.05.028
Keywords
CD137; Cytokine receptor; Autoimmune; Systemic lupus erythematousus
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Funding
- Singapore Ministry of Education
- National Medical Research Council, Singapore
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CD137 is a member of the tumor necrosis factor receptor family, and is involved in the regulation of activation, proliferation, differentiation and apoptosis of T cells, B cells, monocytes, dendritic cells, natural killer cells and granulocytes. Here report that soluble forms of murine CD137 (sCD137) are generated by differential splicing and are released by activated T cells. Levels of sCD137 correlate with cell activation and the extent of cell death but not with cellular proliferation. While CD8(+) T cells express significantly more cell surface CD137 than CD4(+) T cells, both T cell subsets express similar levels of sCD137, resulting a twofold increased ratio of soluble to cell surface CD137 for CD4(+) T cells. sCD137 exists as a trimer and a higher order multimer, can bind to CD137 ligand, and inhibits secretion of IL-10 and IL-12. sCD137 is present in sera of mice with autoimmune disease but is undetectable in sera of healthy mice. (C) 2008 Elsevier Ltd. All rights reserved.
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