Journal
MOLECULAR HUMAN REPRODUCTION
Volume 19, Issue 12, Pages 794-798Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molehr/gat075
Keywords
oocyte maturation; embryology
Funding
- National Health and Medical Research Council of Australia [APP1023210, APP627007]
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The history of in vitro maturation (IVM) of mammalian oocytes, especially of human oocytes, holds a special place for Robert Edwards. He was the first to comprehensively examine and demonstrate maturation of human oocytes in vitro and in so doing he changed the course of medicine by fertilizing them in vitro. In reviewing his contribution, we have examined the state of the field at the time and discuss his pioneering insights into mammalian oocyte biology. We will also discuss how some of the major concepts and challenges identified by Edwards 50 years ago remain among the major challenges facing IVM today.
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